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MilliporeSigma, SystImmune Partner for Bi-specific Antibody Development

CHOZN expression system to be used to accelerate development timelines

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By: Tim Wright

Editor-in-Chief, Contract Pharma

MilliporeSigma said that its CHOZN expression system will be used by SystImmune, a Seattle-based biotechnology company, for commercial development of a bi-specific antibody therapeutic.

The CHOZN expression system is designed to deliver manufacturing-ready robust and stable producing clones with a workflow that minimizes the resources needed to complete a cell line development project. As a result, users are able to quickly evaluate more molecules in their pipeline.

“When compared with alternate expression systems, our CHOZN system offers a turnkey solution that consistently delivers shortened development timelines,” said Udit Batra, chief executive officer, MilliporeSigma.

MilliporeSigma’s CHOZN expression system is based on a GS -/- Chinese hamster ovary (CHO) cell line.

“With only two scientists in our cell science department, we were able to generate more than 10 stable cell lines using this platform in a single year,” said Camilla Wang, scientist, SystImmune. “The CHOZN platform outperformed other systems in many ways. It is easy to use, requires less time to generate final single cell clones, and most of all, the expression level is consistently higher compared to the other approaches.”

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